uv

Uv replaces all of them. It's a single tool that handles Python version management, virtual environments, package installation, and project management. And it does it 10-100x faster than pip because it's written in Rust.

Everything is free. No paid tier, no cloud, no account. Install it and it replaces pip, pip-tools, pyenv, virtualenv, and pipx in one binary. The speed difference isn't marginal. It's 'blink and it's done' versus 'go get coffee.'

The catch: it's from Astral (the Ruff team), which doesn't have a monetization model yet. That's a risk if you're betting your toolchain on it long-term. And some edge cases with legacy packages that rely on setup.py quirks can still trip it up. But the Python community has clearly voted.